منابع مشابه
Clinical and biologic activity of an estrogenic herbal combination (PC-SPES) in prostate cancer.
BACKGROUND Herbal mixtures are popular alternatives to demonstrated therapies. PC-SPES, a commercially available combination of eight herbs, is used as a nonestrogenic treatment for cancer of the prostate. Since other herbal medicines have estrogenic effects in vitro, we tested the estrogenic activity of PC-SPES in yeast and mice and in men with prostate cancer. METHODS We measured the estrog...
متن کاملHerbal composition PC-SPES for management of prostate cancer: identification of active principles.
BACKGROUND The herbal mixture PC-SPES, used to manage advanced prostate cancer, has proven thrombogenic and highly estrogenic in clinical trials. However, attempts to identify the active compounds in PC-SPES have yielded incongruous results. Moreover, warfarin was identified in the serum of a patient taking PC-SPES who experienced a bleeding disorder. To determine the active components in PC-SP...
متن کاملPC-SPES, a dietary supplement for the treatment of hormone-refractory prostate cancer.
OBJECTIVE To assess the effectiveness of PC-SPES, a dietary supplement containing eight herbal extracts, which is a popular alternative therapy among patients with hormone-refractory prostate cancer; anecdotal reports claim that this agent provides relief of metastatic pain, improvements in quality of life and reduction of prostatic specific antigen (PSA) level. PATIENTS AND METHODS Sixteen m...
متن کاملIn vivo effect of PC-SPES on prostate growth and hepatic CYP3A expression in rats.
PC-SPES, a proprietary mixture composed of eight different herbs, is used worldwide as an alternative treatment by prostate cancer patients. It has been suggested that the clinical and in vitro antitumor activity exhibited by PC-SPES may be due to estrogenic activity, which in turn may be mediated by the presence of undeclared prescription drug contaminants. Here, we evaluated the in vivo effec...
متن کاملIdentification of Activity Pathways in Prostate Carcinoma Molecular Effects of the Herbal Compound PC-SPES
Clinical trials of the herbal preparation PC-SPES have demonstrated substantial responses in patients with advanced prostate cancer. Biochemical assays and clinical observations suggest that the effects of PC-SPES are mediated at least in part through estrogenic activity, although the mechanism(s) remains largely undefined. In this study, we used cDNA microarray analysis to identify gene expres...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2001
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/131.1.164s